Combigan Eye Drops, 5ml

Treatment of high pressure inside the eye due to glaucoma(open-angle type) or other eye diseases (e.g., ocular hypertension).

Active Ingredients: Brimonidine tartrate and Timolol.

Original price was: ₦18,700.00.Current price is: ₦17,980.00. or subscribe and save 5%

Availability: Out of stock


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Combigan Eye Drops, 5mL
Original price was: ₦18,700.00.Current price is: ₦17,980.00. or subscribe and save 5%
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Combigan Eye Drops, 5mL

Combigan Eye Drops is an eye drop that is used to control glaucoma. It contains two different medicines (brimonidine and timolol) that both reduce high pressure in the eye. Brimonidine belongs to a group of medicines called alpha-2 adrenergic receptor agonists. Timolol belongs to a group of medicines called beta-blockers.

COMBIGAN is prescribed to reduce high pressure in the eye when beta-blocker eye drops used alone are not enough.

What is Glaucoma?

Glaucoma is a common eye condition where the optic nerve, which connects the eye to the brain, becomes damaged.

It’s usually caused by fluid building up in the front part of the eye, which increases pressure inside the eye.

Glaucoma can lead to loss of vision if it’s not diagnosed and treated early.

It can affect people of all ages, but is most common in adults in their 70s and 80s.

Glaucoma does not usually cause any symptoms to begin with.

It tends to develop slowly over many years and affects the edges of your vision (peripheral vision) first.

For this reason, many people do not realise they have glaucoma, and it’s often only picked up during a routine eye test.

If you do notice any symptoms, they might include blurred vision, or seeing rainbow-coloured circles around bright lights.

Both eyes are usually affected, although it may be worse in 1 eye.

Very occasionally, glaucoma can develop suddenly and cause:

  • intense eye pain
  • nausea and vomiting
  • red eye
  • headache
  • tenderness around the eyes
  • seeing rings around lights
  • blurred vision

There are several different types of glaucoma.

The most common is called primary open angle glaucoma. This tends to develop slowly over many years.

It’s caused by the drainage channels in the eye becoming gradually clogged over time.

Other types of glaucoma include:

  • acute angle closure glaucoma – an uncommon type caused by the drainage in the eye becoming suddenly blocked, which can raise the pressure inside the eye very quickly
  • secondary glaucoma – caused by an underlying eye condition, such as inflammation of the eye (uveitis)
  • childhood glaucoma (congenital glaucoma) – a rare type that occurs in very young children, caused by an abnormality of the eye.

Glaucoma can occur for a number of reasons.

Most cases are caused by a build-up of pressure in the eye when fluid is unable to drain properly.

This increase in pressure then damages the nerve that connects the eye to the brain (optic nerve).

It’s often unclear why this happens, although certain things can increase the risk, including:

  • your age – glaucoma becomes more common as you get older
  • your ethnicity – people of African, Caribbean or Asian origin are at a higher risk
  • your family history – you’re more likely to develop glaucoma if you have a parent or sibling with the condition
  • other medical conditions – such as short-sightednesslong-sightedness and diabetes

It’s not clear whether you can do anything to prevent glaucoma, but having regular eye tests should pick it up as early as possible.

Glaucoma can usually be detected during a routine eye test at opticians, often before it causes any noticeable symptoms.

Combigan Eye Drops Reviews

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What is the price of Combigan Eye Drops in Nigeria?

The price of Combigan Eye Drops is N17,980

Where can you buy Combigan Eye Drops In Nigeria?

You can Buy Combigan Eye Drops at Asset Pharmacy Lagos Nigeria, Nigeria’s Largest Online Pharmacy.

Combigan Eye Drops is a prescription drug that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent.

You will be required to send Asset Pharmacy your prescription



How to Use

How to use Combigan Eye Drops

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. COMBIGAN must not be used in infants below 2 years of age. COMBIGAN should not usually be used in children and adolescents (from 2 to 17 years).

The recommended dose is one drop of COMBIGAN, twice a day about 12 hours apart. Do not change the dose or stop taking it without speaking to your doctor.

If you have other eye drops as well as COMBIGAN, leave at least 5 minutes between using COMBIGAN and the other eye drops.

Instructions for use

You must not use the bottle if the tamper-proof seal on the bottle neck is broken before you first begin to use it.

Wash your hands before opening the bottle. Tilt your head back and look at the ceiling.

1. Gently pull down the lower eyelid until there is a small pocket.
2. Turn the bottle upside down and squeeze it to release one drop into each eye that needs treatment.
3. Let go of the lower lid, and close your eye.
4. Keep the eye closed and press your finger against the corner of your eye (the side where your eye meets your nose) for two minutes. This helps stop COMBIGAN getting into the rest of the body.


If a drop misses your eye, try again.

To avoid contamination, do not let the tip of the bottle touch your eye or anything else. Put the screw-cap back on to close the bottle, straight after you have used it.

If you use more COMBIGAN than you should


If you use more COMBIGAN than you should, it is unlikely to cause you any harm. Put your next drop in at the usual time. If you are worried, talk to your doctor or pharmacist.

Babies and Children

Several cases of overdose have been reported in babies and children receiving brimonidine (one of the ingredients of COMBIGAN) as part of medical treatment for glaucoma. Signs include sleepiness, floppiness, low body temperature, paleness and breathing difficulties. Should this happen, contact your doctor immediately.

Adults and Children

If COMBIGAN has been accidentally swallowed then you should contact your doctor immediately.

If you forget to use COMBIGAN

If you forget to use COMBIGAN, use a single drop in each eye that needs treatment as soon as you remember, and then go back to your regular routine. Do not take a double dose to make up for a forgotten dose.

If you stop using COMBIGAN

COMBIGAN should be used every day to work properly.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Product Details

Product Information of Combigan Eye Drops

What you need to know before you use COMBIGAN

Do not use COMBIGAN:

  • if you are allergic (hypersensitive) to brimonidine tartrate, timolol, beta-blockers or any of the other ingredients of this medicine (listed in section 6). Symptoms of an allergic reaction may include swelling of the face, lips and throat, wheeziness, feeling faint, shortness of breath, itching or redness around the eye.
  • if you have now or have had in the past respiratory problems such as asthma, severe chronic obstructive bronchitis (severe lung disease which may cause wheeziness, difficulty in breathing and/or long-standing cough).
  • if you have heart problems such as low heart rate, heart failure, heart beat disorders (unless controlled by a pacemaker).
  • if you are taking monoamine oxidase (MAO) inhibitors or certain other antidepressant drugs.


If you think any of these points apply to you, do not use COMBIGAN until you have talked again to your doctor.

Warnings and precautions

Talk to your doctor before using COMBIGAN

  • if you have now or have had in the past
    • coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, low blood pressure
    • disturbances of heart rate such as slow heart beat
    • breathing problems, asthma or chronic obstructive pulmonary disease
    • poor blood circulation disease (such as Raynaud’s disease or Raynaud’s syndrome)
    • diabetes as timolol may mask signs and symptoms of low blood sugar levels
    • over activity of the thyroid gland as timolol may mask signs and symptoms
    • kidney or liver problems
    • tumour of the adrenal gland
    • eye surgery to lower the pressure in your eye
  • if you suffer or have suffered from any allergy (e.g. hayfever, eczema) or a severe allergic reaction be aware that the usual dose of adrenaline used to control a severe reaction may need to be increased.
  • Tell the doctor before you have an operation that you are using COMBIGAN, as the timolol may change effects of some medicines during anaesthesia.


Children and adolescents

COMBIGAN should not be used in children less than 2 years old and should not usually be used in children aged 2 to 17.

Other medicines and COMBIGAN

COMBIGAN can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor or pharmacist if you are taking, have recently taken or might take other medicines, including medicines for any condition, even if unrelated to your eye condition, including medicines obtained without a prescription. There are a number of medicines which may interfere with COMBIGAN, so it is particularly important to tell your doctor if you are taking:

  • pain killers
  • medicines to help you sleep or for anxiety
  • medicines to treat high blood pressure (hypertension)
  • medicines for heart conditions (for example an abnormal heartbeat) such as beta blockers, digoxin or quinidine (used to treat heart conditions and some types of malaria)
  • medicines to treat diabetes or high blood sugar
  • medicines for depression such as fluoxetine and paroxetine
  • another eye drop used to lower high pressure in the eye (glaucoma)
  • medicines to treat severe allergic reactions
  • medicines that affect some of the hormones in your body, like adrenaline and dopamine
  • medicines that affect the muscles in your blood vessels
  • medicines to treat heartburn or stomach ulcers


If the dose of any of your current medicines is changed or if you are regularly consuming alcohol you should tell your doctor.

If you are due to have an anaesthetic, you should tell the doctor or dentist that you are taking COMBIGAN.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Do not use COMBIGAN if you are pregnant unless your doctor considers it necessary.

Do not use COMBIGAN if you are breast-feeding. Timolol may get into your milk. Ask your doctor for advice before taking any medicine during breast-feeding.

Driving and using machines

COMBIGAN may cause drowsiness, tiredness or blurred vision in some patients. Do not drive or use any tools or machines until the symptoms have cleared. If you experience any problems, talk to your doctor.

COMBIGAN contains benzalkonium chloride

This medicine contains 0.25 mg benzalkonium chloride in each 5 ml of solution which is equivalent to 0.05 mg/ml.

  • Benzalkonium chloride may be absorbed by soft contact lenses and may change the colour of the contact lenses. You should remove contact lenses before using this medicine and put them back 15 minutes afterwards.
  • Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or disorders of the cornea (the clear layer at the front of the eye). If you feel abnormal eye sensation, stinging or pain in the eye after using this medicine, talk to your doctor


COMBIGAN contains phosphates:

This medicine contains 52.9 mg phosphates in each 5 ml of solution which is equivalent to 10.58 mg/ml.

If you suffer from severe damage to the clear layer at the front of the eye (the cornea), phosphates may cause in very rare cases cloudy patches on the cornea due to calcium build-up during treatment.

Side Effects

Side Effects of Combigan Eye Drops

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any of the following side effects, please contact your doctor immediately:

  • Heart failure (eg. chest pain) or irregular heart rate
  • Increased or decreased heart rate or low blood pressure

Affecting the eye

Very common (May affect more than 1 in 10 people) :

  • Eye redness or burning.

Common (May affect up to 1 in 10 people):

  • Stinging or pain in the eye
  • Allergic reaction in the eye or on the skin around the eye
  • Small breaks in the surface of the eye (with or without inflammation)
  • Swelling, redness or inflammation of the eyelid
  • Irritation, or a feeling of something in the eye
  • Itching of the eye and eyelid
  • Follicles or white spots on the see through layer which covers the surface of the eye
  • Vision disturbance
  • Tearing
  • Eye dryness
  • Sticky eyes

Uncommon (May affect up to 1 in 100 people):

  • Difficulty in seeing clearly
  • Swelling or inflammation of the see-through layer which covers the surface of the eye
  • Tired eyes
  • Sensitivity to light
  • Eyelid pain
  • Whitening of the see-through layer which covers the surface of the eyes
  • Swelling or areas of inflammation under the surface of the eye
  • Floaters in front of the eyes

Not known (Frequency cannot be estimated from the available data):

  • Blurred vision

Affecting the body:

Common (May affect up to 1 in 10 people):

  • High blood pressure
  • Depression
  • Sleepiness
  • Headache
  • Dry mouth
  • General weakness

Uncommon (May affect up to 1 in 100 people):

  • Heart failure
  • Irregular heart rate
  • Light-headedness
  • Fainting
  • Dry nose
  • Taste disturbance
  • Nausea
  • Diarrhoea

Not known (Frequency cannot be estimated from the available data):

  • Increased or decreased heart rate
  • Low blood pressure
  • Face redness

Some of these effects may be due to an allergy to any of the ingredients. Additional side effects have been seen with brimonidine or timolol and therefore may potentially occur with COMBIGAN.

The following additional side effects have been seen with brimonidine:

  • Inflammation within eye, small pupils, difficulty sleeping cold-like symptoms shortness of breath, symptoms involving the stomach and digestion, general allergic reactions, skin reactions including redness, face swelling itching rash and widening of blood vessels.

Like other medicines applied into eyes, COMBIGAN (brimonidine/timolol) is absorbed into the blood. Absorption of timolol, a beta blocker component of COMGIBAN, may cause similar side effects as seen with intravenous” and /or “oral” beta-blocking agents. Incidence of side effects after topical ophthalmic administration is lower than when medicines are for example, taken by mouth or injected. Listed side effects include reactions seen within the class of beta-blockers when used for treating eye conditions:

  • Generalised allergic reactions, including swelling beneath the skin (that can occur in areas such as the face and limbs, and can obstruct the airway which may cause difficulty swallowing or breathing), hives (or itchy rash), localised and generalised rash, itchiness, severe sudden life threatening allergic reaction
  • Low-blood glucose levels
  • Difficulty in sleeping (insomnia), nightmares, memory loss, hallucination
  • Stroke, reduced blood supply to the brain, increased signs and symptoms of myasthenia gravis (muscle disorder), unusual sensations (like pins and needles).
  • Inflammation in the cornea, detachment of the layer below the retina that contains blood vessels following filtration surgery which may cause visual disturbances, decreased corneal sensitivity, corneal erosion (damage to the front layer of the eyeball), drooping of the upper eyelid (making the eye half closed), double vision
  • Chest pain, oedema (fluid build up), changes in the rhythm or speed of the heartbeat, a type of heart rhythm disorder, heart attack, heart failure
  • Raynaud’s phenomenon, cold hands and feet
  • Constriction of the airways in the lung (predominantly in patients with preexisting disease) difficulty breathing, cough
  • Indigestion , abdominal pain, vomiting
  • Hair loss, skin rash with white silvery coloured appearance (psoriasiform rash) or worsening of psoriasis, skin rash
  • Muscle pain not caused by exercise
  • Sexual dysfunction, decreased libido
  • Muscle weakness/tiredness

Other side effects reported with eye drops containing phosphates:

Cases of corneal calcification have been reported very rarely in association with the use of phosphate containing eye drops in some patients with significantly damaged cornea.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet


Product Ingredients of Combigan Eye Drops

  • The active substances are brimonidine tartrate and timolol.
  • One millilitre of solution contains 2 milligrams of brimonidine tartrate and timolol maleate equivalent to 5 milligrams of timolol.
  • The other ingredients are benzalkonium chloride (a preservative), sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate and purified water.

Small amounts of hydrochloric acid or sodium hydroxide may be added to bring the solution to the correct pH (a measure of the acidity or alkalinity of the solution).


How to store

How to store Combigan Eye Drops

Keep this medicine out of the sight and reach of children.

Keep the bottle in the outer carton to protect it from light.

You should only use one bottle at a time.

Do not use this medicine after the expiry date which is stated on the label of the bottle and the carton after EXP:. The expiry date refers to the last day of that month.

You must throw away the bottle four weeks after you first opened it, even if there are still some drops left. This will help to prevent infections. To help you remember, write down the date that you opened it in the space on the carton.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Patient Information Leaflet

Click here  for the Patient Information Leaflet of Combigan Eye Drops

Prescription Product

This product requires a prescription from your Doctor.

Please follow the instruction received from the pharmacy on how to forward your prescription to the pharmacy after you have paid for the medicine.

A prescription drug is a pharmaceutical medication that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent


Delievry time are estimates. Can vary due to the time of day you order.

Delivery time estimate are subject to the courier company.

Shipping to Lagos cost starts from N1850 Next day delivery

Shipping to Rest Of Nigeria – 2-3 days cost starts from N2000

Shipping to Rest of Africa –  5-7 working days Cost starts from N12000

Shipping to Europe 7 – 14 working days Cost srats from N18000

Shipping to Rest of the world – 7 – 14 days Cost starts from N18000


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