Product Details

Product Information of Hydrochlorothiazide 25mg Tablets

Warnings for people with certain health conditions

For people with kidney problems: Use caution when taking hydrochlorothiazide if you have poor kidney function. This drug is cleared from your body by your kidneys. If your kidneys don’t work as well, this drug may build up in your body and cause more side effects. If your kidney function gets worse, your doctor might stop your treatment with this medication.

For people with kidneys that don’t make enough urine: You can’t take hydrochlorothiazide if your kidneys can’t make enough urine. This drug can cause electrolyte and fluid loss, which may make you produce even less urine.

For people with poor liver function: Use this drug with caution if you have poor liver function or progressive liver disease. Hydrochlorothiazide can cause electrolyte and fluid imbalance. This can make your liver function worse.

For people with lupus: This drug can cause your lupus to flare up.

Warnings for certain groups

For pregnant women: Talk to your doctor if you’re pregnant or plan to become pregnant.

Research in animals hasn’t shown a risk to the fetus when the mother takes the drug. There haven’t been enough studies done in humans to show if the drug poses a risk to the fetus.

This drug should only be used if the potential benefit justifies the risk.

For women who are breastfeeding: Hydrochlorothiazide may pass into breast milk and may cause side effects in a child who is breastfed. Talk with your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors: Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

Hydrochlorothiazide oral tablet can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.

Below is a list of medications that can interact with hydrochlorothiazide. This list does not contain all drugs that may interact with hydrochlorothiazide.

Before taking hydrochlorothiazide, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Barbiturates

If you take these drugs with hydrochlorothiazide, your blood pressure may be lowered too much. You may have symptoms such as feeling dizzy when you stand up after sitting or lying down. Examples of these drugs include:

• phenobarbital
• pentobarbital

Lithium

In general, lithium shouldn’t be taken with hydrochlorothiazide. That’s because hydrochlorothiazide slows the clearance of lithium from your body. This increases your risk of high levels of lithium in your body, which can cause dangerous side effects.

Blood pressure drugs

Taking hydrochlorothiazide with other blood pressure medications can make your blood pressure drop too low. Examples of these drugs include:

• angiotensin-converting enzyme (ACE) inhibitors, such as:
  • lisinopril
  • fosinopril
  • enalapril
• angiotensin receptor blockers (ARBs), such as:
  • losartan
  • valsartan
  • candesartan
• beta-blockers, such as:
  • atenolol
  • metoprolol
  • bisoprolol
• calcium channel blockers, such as:
  • amlodipine
  • verapamil
  • diltiazem

Cholesterol-lowering drugs

Taking hydrochlorothiazide with certain drugs that lower cholesterol levels may make hydrochlorothiazide less effective. This means it may not work as well to treat your blood pressure or swelling. Examples of these cholesterol drugs include:

• cholestyramine
• colestipol

Corticosteroids

Hydrochlorothiazide can lower your electrolyte levels. Taking corticosteroids with hydrochlorothiazide can cause further loss of electrolytes (especially potassium). Low potassium levels can lead to constipation, fatigue, muscle breakdown, and weakness. Examples of these drugs include:

• prednisone
• methylprednisolone

Diabetes drugs

Hydrochlorothiazide can cause high blood sugar levels. If you take hydrochlorothiazide with diabetes drugs, your doctor may increase your dosage of your diabetes medications. Examples of these drugs include:

• insulin
• oral diabetes drugs, such as:
  • metformin
  • glimepiride
  • pioglitazone
  • sitagliptin

Narcotics

Taking hydrochlorothiazide with narcotics can make your blood pressure drop too low. You may have symptoms such as feeling dizzy when you stand up after sitting or lying down. Examples of these drugs include:

• morphine
• codeine

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Taking NSAIDs with hydrochlorothiazide can make hydrochlorothiazide less effective. This means it may not work as well to treat your blood pressure or swelling.

If you’re taking an NSAID with hydrochlorothiazide, your doctor will closely monitor you. Examples of these drugs include:

• ibuprofen
• naproxen