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Malanil Tablets – Atovaquone and Proguanil, 12 Tablets

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Prophylaxis of Malaria

Treatment of acute, uncomplicated Malaria

Suitable for Adults

Active ingredients: Atovaquone 250mg and Proguanil 100mg

20,980.00

Availability: Out of stock

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EAN: N/A SKU: mala250 Categories: , , Tags: ,

Malanil Tablets – Atovaquone and Proguanil, 12 Tablets

Malanil Tablets is antimalarial tablets for the treatment and prevention of Plasmodium falciparum malaria.

Malanil tablets is effective against drug sensitive and drug resistant P. falciparum it is especially recommended for prophylaxis and treatment of P. falciparum malaria in areas where the pathogen may be resistant to other antimalarials.

Benefits of Malanil Tablets

Prevention of Malaria

Malanil® is indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported.

Treatment of Malaria

Malanil is indicated for the treatment of acute, uncomplicated P. falciparum malaria. Malanil has been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance.

Symptoms of Malaria

Symptoms of malaria can develop as quickly as 7 days after you’re bitten by an infected mosquito.

Typically, the time between being infected and when symptoms start (incubation period) is 7 to 18 days, depending on the specific parasite you’re infected with. However, in some cases it can take up to a year for symptoms to develop.

The initial symptoms of malaria are flu-like and include:

  • a high temperature of 38C or above
  • feeling hot and shivery
  • headaches
  • vomiting
  • muscle pains
  • diarrhoea
  • generally feeling unwell

These symptoms are often mild and can sometimes be difficult to identify as malaria.

Complications of Malaria

Can someone who is pregnant or breastfeeding use Malanil Tablets?

Ask your doctor or pharmacist for advice before taking this medicine if you are pregnant, planning a pregnancy, suspect you are pregnant or breast-feeding

Malanil Tablets Reviews

After using Malanil Tablets, it’s helpful to let others know about your experience. Reviews of an item help other users know that medicines received have helped the condition it is claimed for, how well the treatment worked or any issues to be aware of. We invite our users to leave a review of both their treatment and of the service provided. Click on the reviews tab to see if there has been feedback on this item.

What is the price of  Malanil Tablets in Nigeria?

The price of  Malanil Tablets is N15,450

Where can you buy Malanil Tablets In Nigeria?

You can Buy Malanil Tablets at Asset Pharmacy Lagos Nigeria, Nigeria’s Largest Online Pharmacy.

Malanil Tablets is a prescription drug that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent.

You will be required to send Asset Pharmacy your prescription

Brand

Malanil

How to Use

How to take Malanil Tablets

The daily dose should be taken with food or a milky drink at the same time each day.
In the event of vomiting within 1 hour of dosing a repeat dose should be taken.

PROPHYLAXIS:
Prophylaxis should start 1 to 2 days before entering a malaria-endemic area, and be
continued daily until 7 days after leaving the area.
Dosage in Adults:-
One MALANIL tablet (high strength; 250 mg atovaquone/100 mg proguanil) daily.
Dosage in Children:-
11-20 kg body-weight -One MALANIL low strength tablet (low strength;
62.5 mg atovaquone/25 mg proguanil) daily.
21-30 kg body-weight -Two MALANIL low strength tablets as a single dose
daily.
31-40 kg body-weight -Three MALANIL low strength tablets as a single dose
daily.
Greater than 40 kg body-weight -One MALANIL tablet (high strength) daily.

TREATMENT:
Dosage in Adults:-
Four MALANIL tablets (high strength; total daily dose 1g atovaquone/400 mg proguanil hydrochloride) as a single dose for three consecutive days.
Dosage in Children:-
11-20 kg body-weight – One MALANIL tablet (high strength) daily for three
consecutive days.
21-30 kg body-weight – Two MALANIL tablets (high strength) as a single dose
for three consecutive days.
31-40 kg body-weight – Three MALANIL tablets (high strength) as a single dose
for three consecutive days.
Greater than 40 kg body-weight – Four MALANIL tablets (high strength) as a single dose for three consecutive days.
Dosage in the Elderly (Prophylaxis and Treatment):-
A pharmacokinetic study indicates that no dosage adjustments are needed in the elderly

Product Details

Product Information of Malanil Tablets

Contraindications
MALANIL is contraindicated in individuals with known hypersensitivity to atovaquone or proguanil hydrochloride or any component of the formulation.
MALANIL is contraindicated for prophylaxis of P. falciparum malaria in patients with severe renal impairment (creatinine clearance less than 30 mL/min).

Warnings and Precautions
MALANIL has not been evaluated for the treatment of cerebral malaria or other severe manifestations of complicated malaria including hyperparasitaemia, pulmonary oedema or renal failure.
Safety and effectiveness of MALANIL for the treatment and prophylaxis of malaria in paediatric patients who weigh less than 11 kg has not been established.
In the event of recrudescent infections due to P. falciparum or failure of
chemoprophylaxis, patients should be treated with a different blood schizonticide.
Parasite relapse occurred commonly when P. vivax malaria was treated with MALANIL alone. Travellers with intense exposure to P. vivax or P. ovale, and those who develop malaria caused by either of these parasites, will require additional treatment with a drug such as primaquine, that is active against hypnozoites.
Persons taking MALANIL for prophylaxis or treatment of malaria should take a repeat dose if they vomit within 1 hour of dosing. In the event of diarrhoea, normal dosing should be continued. Absorption of atovaquone may be reduced in patients with diarrhoea or vomiting, but diarrhoea or vomiting was not associated with reduced efficacy in clinical trials of MALANIL for malaria prophylaxis. However, as with other antimalarial agents, patients with diarrhoea or vomiting should be advised to continue to comply with personal protection measures (repellants, bednets).
In patients with acute malaria who present with diarrhoea or vomiting, alternative therapy should be considered. If MALANIL is used to treat malaria in these patients, parasitaemia should be closely monitored.
Parasitaemia should be closely monitored in patients receiving concurrent
metoclopramide or tetracycline (see Interactions).
The concomitant administration of MALANIL and rifampicin or rifabutin is not
recommended (see Interactions)

Interactions
Proguanil may potentiate the anticoagulant effect of warfarin and other coumarin based anticoagulants. The mechanism of this potential drug interaction has not been established.
Caution is advised when initiating or withdrawing malaria prophylaxis or treatment with atovaquone-proguanil in patients on continuous treatment with coumarin based anticoagulants.
Concomitant treatment with tetracycline, metoclopramide, rifampicin and rifabutin have been associated with significant decreases in plasma concentrations of atovaquone (see Warnings and Precautions).
Concomitant administration of atovaquone and indinavir results in a decrease in the Cmin of indinavir (23% decrease; 90% CI: 8 to 35%). Caution should be exercised when prescribing atovaquone with indinavir due to the decrease in trough levels of indinavir.
Atovaquone is highly protein bound (greater than 99%) but does not displace other highly protein bound drugs in vitro, indicating significant drug interactions arising from displacement are unlikely.

Pregnancy and Lactation
Pregnancy:-
The safety of atovaquone and proguanil hydrochloride when administered concurrently for use in human pregnancy has not been established.
Reproductive toxicity studies in animals did not indicate any teratogenic potential at dosages of atovaquone:proguanil hydrochloride of up to 50:20 mg/kg/day in the rat or 100:40 mg/kg/day in the rabbit. In rabbits given atovaquone alone at dosages up to 1200 mg/kg/day, an increased incidence of resorptions and decreased length and weight of foetuses was noted. These effects were likely to be secondary to toxicity of atovaquone in maternal animals.
However, as animal studies are not always predictive of human response the use of
MALANIL in pregnancy should only be considered if the expected benefit to the mother outweighs the risk to the foetus.
The proguanil component of MALANIL acts by inhibiting parasitic dihydrofolate
reductase. There are no clinical data indicating that folate supplementation diminishes drug efficacy. For women of childbearing age receiving folate supplements to prevent neural tube birth defects, such supplements may be continued while taking MALANIL.

Lactation:-
The atovaquone concentrations in milk, in a rat study, were 30% of the concurrent
atovaquone concentrations in maternal plasma. It is not known whether atovaquone is excreted in human milk.
Proguanil is excreted in human milk in small quantities.
It is not recommended that mothers receiving MALANIL breast feed their babies.

Side Effects

Side Effects of Malanil Tablets

A summary of adverse events associated with the use of MALANIL, atovaquone or
progunail hydrochloride is provided below:
Blood & Lymphatic system disorders
Common: Anaemia1
, neutropenia2
Not Known: Pancytopenia in patients with severe renal impairment4
Immune system disorders
Not Known: Angioedema4
, anaphylaxis3
, vasculitis4
Metabolism and nutritional disorders
Common: Hyponatraemia2
, anorexia

Uncommon: Elevated amylase levels2
Psychiatric disorders
Rare: Hallucinations1
Nervous system disorders
Very common: Headache1
Common: Insomnia1
, dizziness1
Gastrointestinal disorders
Very common: Abdominal pain1
, nausea2
, vomiting1
, diarrhoea1
Uncommon: Stomatitis1
Not Known: Gastric intolerance4
, oral ulceration4
Hepatobiliary disorders
Common: Elevated liver enzyme levels 2
Not Known: Hepatitis3
, Cholestasis4
Clinical trial data for atovaquone-proguanil indicated that
abnormalities in liver function tests were reversible and
not associated with untoward clinical events
Skin and subcutaneous tissue disorders
Common Rash1
Uncommon: Hair loss1
, urticaria1
Not Known Stevens-Johnson Syndrome3
, erthema multiforme3
General disorders and administration site conditions
Common: Fever
Respiratory, thoracic and mediastinal disorders
Common: Cough

Ingredients

Product Ingredients of Malanil Tablets

MALANIL tablet contains 250 mg atovaquone and 100 mg proguanil
hydrochloride

Patient Information Leaflet

Click here  for the Patient Information Leaflet of Malanil Tablets

Prescription Product

This product requires a prescription from your Doctor.

Please follow the instruction received from the pharmacy on how to forward your prescription to the pharmacy after you have paid for the medicine.

A prescription drug is a pharmaceutical medication that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent

Delivery

Delievry time are estimates. Can vary due to the time of day you order.

Delivery time estimate are subject to the courier company.

Shipping to Lagos cost starts from N1850 Next day delivery

Shipping to Rest Of Nigeria – 2-3 days cost starts from N2000

Shipping to Rest of Africa –  5-7 working days Cost starts from N12000

Shipping to Europe 7 – 14 working days Cost srats from N18000

Shipping to Rest of the world – 7 – 14 days Cost starts from N18000

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