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Treviamet 50mg 1000mg Tablets – Sitagliptin Metformin, 14 Tablets

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  • Treatment for Type 2 Diabetes
  • Active Ingredient: 50mg Sitagliptin 1000mg Metformin
  • Suitable for Adults and Children over 18 Years
  • Not Suitable in Pregnancy or Breastfeeding

2,600.00

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Treviamet 50mg 1000mg Tablets – Sitagliptin Metformin, 14 Tablets

What is Treviamet 50mg 1000mg Tablets?

Treviamet 50mg 1000mg Tablets contains two different medicines called sitagliptin and metformin.
• sitagliptin belongs to a class of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors)
• metformin belongs to a class of medicines called biguanides.
They work together to control blood sugar levels in adult patients with a form of diabetes called ‘type 2 diabetes mellitus’. This medicine helps to increase the levels of insulin produced after a meal and lowers the amount of sugar made by your body.
Along with diet and exercise, this medicine helps lower your blood sugar. This medicine can be used alone or with certain other medicines for diabetes (insulin, sulphonylureas, or glitazones).

What is Treviamet used for?

  • As initial therapy in patients with type 2 diabetes mellitus to improve glycemic control when diet and exercise do not provide adequate glycemic control.
  • As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus inadequately controlled on Metformin HCl or Sitagliptin alone or in patients already being treated with the combination of Sitagliptin and Metformin HCl.
  • In triple combination with a sulphonylurea as an adjunct to diet and exercise in patients with type 2 diabetes mellitus inadequately controlled on their maximal tolerated dose of Metformin HCl and a sulphonylurea.
  • In triple combination with a peroxisome proliferator-activated receptor gamma (PPARγ) agonist (thiazolidinedione) as an adjunct to diet and exercise in patients inadequately controlled on their maximal tolerated dose of Metformin HCl and a PPARγ agonist.
  • In patients with type 2 diabetes mellitus as an adjunct to diet and exercise to improve glycemic control in combination with insulin

What is type 2 diabetes?

Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems like heart disease, kidney disease, blindness, and amputation.

  • Type 2 diabetes is a common condition that causes the level of sugar (glucose) in the blood to become too high.
  • It can cause symptoms like excessive thirst, needing to pee a lot and tiredness. It can also increase your risk of getting serious problems with your eyes, heart and nerves.
  • It’s a lifelong condition that can affect your everyday life. You may need to change your diet, take medicines and have regular check-ups.
  • It’s caused by problems with a chemical in the body (hormone) called insulin. It’s often linked to being overweight or inactive, or having a family history of type 2 diabetes.

Symptoms of Type 2 Diabetes

Many people have type 2 diabetes without realising. This is because symptoms don’t necessarily make you feel unwell.

Symptoms of type 2 diabetes include:

  • peeing more than usual, particularly at night
  • feeling thirsty all the time
  • feeling very tired
  • losing weight without trying to
  • itching around your penis or vagina, or repeatedly getting thrush
  • cuts or wounds taking longer to heal
  • blurred vision

You’re more at risk of developing type 2 diabetes if you:

  • are over 40 – or 25 for south Asian people
  • have a close relative with diabetes – such as a parent, brother or sister
  • are overweight or obese
  • are of south Asian, Chinese, African Caribbean or black African origin – even if you were born in the UK

Understanding your type 2 diabetes medication

Most people need medicine to control their type 2 diabetes.

The medicine helps keep your blood sugar level as normal as possible to prevent health problems. You’ll have to take it for the rest of your life.

Diabetes usually gets worse over time, so your medicine or dose may need to change.

Adjusting your diet and being active is also necessary to keep your blood sugar level down.

How to manage your diabetes

A healthy diet and keeping active will help you manage your blood sugar level. It will also help you to control your weight and generally feel better.

YOU CAN EAT MANY TYPES OF FOODS

There’s nothing you can’t eat if you have type 2 diabetes, but you’ll have to limit certain foods.

You should:

  • eat a wide range of foods – including fruit, vegetables and some starchy foods like pasta
  • keep sugar, fat and salt to a minimum
  • eat breakfast, lunch and dinner every day – don’t skip meals

If you need to change your diet, it might be easier to make small changes every week.

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Price of  Treviamet 50mg 1000mg Tablets in Nigeria

Treviamet 50mg 1000mg Tablets is available on Asset Pharmacy Lagos Nigeria, Nigeria’s Largest Online Pharmacy

The brand version Trevia is Januvia

Patient information leaflet

Brand

Trevia

How to Use

How to take Treviamet
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist
if you are not sure.
• Take one tablet:
• twice daily by mouth
• with meals to lower your chance of an upset stomach.
• Your doctor may need to increase your dose to control your blood sugar.
• If you have reduced kidney function, your doctor may prescribe a lower dose.
You should continue the diet recommended by your doctor during treatment with this medicine and take care that your carbohydrate intake is equally distributed over the day.
This medicine alone is unlikely to cause abnormally low blood sugar (hypoglycaemia). When this medicine is used with a sulphonylurea medicine or with insulin, low blood sugar can occur and your doctor may reduce the dose of your sulphonylurea or insulin.

Product Details

What you need to know before you take Treviamet
Do not take Treviamet:
– if you are allergic to sitagliptin or metformin or any of the other ingredients of this medicine
(listed in section 6).
– if you have severely reduced kidney function
– if you have uncontrolled diabetes, with e.g. severe hyperglycaemia (high blood glucose),
nausea, vomiting, diarrhoea, rapid weight loss, lactic acidosis (see “Risk of lactic acidosis” below) or ketoacidosis. Ketoacidosis is a condition in which substances called ‘ketone bodies’ accumulate in the blood and which can lead to diabetic pre-coma. Symptoms include stomach pain, fast and deep breathing, sleepiness or your breath developing an unusual fruity smell.
– if you have a severe infection or are dehydrated
2
– if you are going to have an X-ray where you will be injected with a dye. You will need to stop taking Treviamet at the time of the X-ray and for 2 or more days after as directed by your doctor,
depending on how your kidneys are working
– if you have recently had a heart attack or have severe circulatory problems, such as ‘shock’ or breathing difficulties
– if you have liver problems
– if you drink alcohol to excess (either every day or only from time to time)
– if you are breast-feeding
Do not take Janumet if any of the above apply to you and talk with your doctor about other ways of managing your diabetes. If you are not sure, talk to your doctor, pharmacist or nurse before taking Treviamet
Warnings and precautions
Cases of inflammation of the pancreas (pancreatitis) have been reported in patients receiving Treviamet (see section 4).
If you encounter blistering of the skin it may be a sign for a condition called bullous pemphigoid.
Your doctor may ask you to stop Janumet.
Risk of lactic acidosis
Treviamet may cause a very rare, but very serious side effect called lactic acidosis, particularly if your kidneys are not working properly. The risk of developing lactic acidosis is also increased with uncontrolled diabetes, serious infections, prolonged fasting or alcohol intake, dehydration (see further information below), liver problems and any medical conditions in which a part of the body has a
reduced supply of oxygen (such as acute severe heart disease).
If any of the above apply to you, talk to your doctor for further instructions.
Stop taking Treviamet for a short time if you have a condition that may be associated with dehydration (significant loss of body fluids) such as severe vomiting, diarrhoea, fever, exposure to heat or if you drink less fluid than normal. Talk to your doctor for further instructions.
Stop taking Treviamet and contact a doctor or the nearest hospital immediately if you experience some of the symptoms of lactic acidosis, as this condition may lead to coma.
Symptoms of lactic acidosis include:
– vomiting
– stomachache (abdominal pain)
– muscle cramps
– a general feeling of not being well with severe tiredness
– difficulty in breathing
– reduced body temperature and heartbeat
Lactic acidosis is a medical emergency and must be treated in a hospital.
Talk to your doctor or pharmacist before taking Janumet:
– if you have or have had a disease of the pancreas (such as pancreatitis)
– if you have or have had gallstones, alcohol dependence or very high levels of triglycerides (a form of fat) in your blood. These medical conditions can increase your chance of getting pancreatitis (see section 4)
– if you have type 1 diabetes. This is sometimes called insulin-dependent diabetes
– if you have or have had an allergic reaction to sitagliptin, metformin, or Janumet (see section 4)
– if you are taking a sulphonylurea or insulin, diabetes medicines, together with Treviamet, as you may experience low blood sugar levels (hypoglycaemia). Your doctor may reduce the dose of your sulphonylurea or insulin
If you need to have major surgery you must stop taking Janumet during and for some time after the procedure. Your doctor will decide when you must stop and when to restart your treatment with Treviamet.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before taking Treviamet.
During treatment with Treviamet, your doctor will check your kidney function at least once a year or more frequently if you are elderly and/or if you have worsening kidney function.
Children and adolescents
Children and adolescents below 18 years should not use this medicine. It is not effective in children and adolescents between the ages of 10 and 17 years. It is not known if this medicine is safe and effective when used in children younger than 10 years.
Other medicines and Treviamet
If you need to have an injection of a contrast medium that contains iodine into your bloodstream, for example, in the context of an X-ray or scan, you must stop taking Treviamet before or at the time of the injection. Your doctor will decide when you must stop and when to restart your treatment with Treviamet
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. You may need more frequent blood glucose and kidney function tests, or your doctor may need to adjust the dosage of Janumet. It is especially important to mention the following:
• medicines (taken by mouth, inhalation, or injection) used to treat diseases that involve inflammation, like asthma and arthritis (corticosteroids)
• medicines which increase urine production (diuretics)
• medicines used to treat pain and inflammation (NSAID and COX-2-inhibitors, such as ibuprofen and celecoxib)
• certain medicines for the treatment of high blood pressure (ACE inhibitors and angiotensin II receptor antagonists)
• specific medicines for the treatment of bronchial asthma (β-sympathomimetics)
• iodinated contrast agents or alcohol-containing medicines
• certain medicines used to treat stomach problems such as cimetidine
• ranolazine, a medicine used to treat angina
• dolutegravir, a medicine used to treat HIV infection
• vandetanib, a medicine used to treat a specific type of thyroid cancer (medullary thyroid cancer)
• digoxin (to treat irregular heartbeat and other heart problems). The level of digoxin in your blood may need to be checked if taking with Treviamet.
Treviamet with alcohol
Avoid excessive alcohol intake while taking Janumet since this may increase the risk of lactic acidosis (see section “Warnings and precautions”).
Pregnancy and breast-feeding
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. You should not take this medicine
during pregnancy or if you are breast-feeding. See section 2, Do not take Janumet.
Driving and using machines
This medicine has no or negligible influence on the ability to drive and use machines. However, dizziness and drowsiness have been reported with sitagliptin, which may affect your ability to drive or use machines.
Taking this medicine in combination with medicines called sulphonylureas or with insulin can cause hypoglycaemia, which may affect your ability to drive and use machines or work without safe foothold.
Treviamet contains sodium
This medicine contains less than 1 mmol sodium (23 mg) per tablet, that is to say essentially ‘sodiumfree’

How to store Janumet
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister and the carton after ‘EXP’.
The expiry date refers to the last day of the month.
Do not store above 30°C.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Side Effects

Like all medicines, Treviamet can cause side effects, although not everybody gets them.
STOP taking Treviamet and contact a doctor immediately if you notice any of the following serious side effects:
• Severe and persistent pain in the abdomen (stomach area) which might reach through to your back with or without nausea and vomiting, as these could be signs of an inflamed pancreas (pancreatitis).
Treviamet may cause a very rare (may affect up to 1 in 10,000 people), but very serious side effect called lactic acidosis (see section “Warnings and precautions”). If this happens, you must stop taking Treviamet and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma.

If you have a serious allergic reaction (frequency not known), including rash, hives, blisters on the skin/peeling skin and swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing, stop taking this medicine and call your doctor right away. Your doctor may prescribe a medicine to treat your allergic reaction and a different medicine for your diabetes.
Some patients taking metformin have experienced the following side effects after starting sitagliptin:
Common (may affect up to 1 in 10 people): low blood sugar, nausea, flatulence, vomiting
Uncommon (may affect up to 1 in 100 people): stomachache, diarrhoea, constipation, drowsiness
Some patients have experienced diarrhoea, nausea, flatulence, constipation, stomachache or vomiting when starting the combination of sitagliptin and metformin together (frequency is common).
Some patients have experienced the following side effects while taking this medicine with a sulphonylurea such as glimepiride:
Very common (may affect more than 1 in 10 people): low blood sugar
Common: constipation
Some patients have experienced the following side effects while taking this medicine in combination with pioglitazone:
Common: swelling of the hands or legs
Some patients have experienced the following side effects while taking this medicine in combination
with insulin:
Very common: low blood sugar
Uncommon: dry mouth, headache
Some patients have experienced the following side effects during clinical studies while taking sitagliptin alone (one of the medicines in Janumet) or during post-approval use of Treviamet or sitagliptin alone or with other diabetes medicines:
Common: low blood sugar, headache, upper respiratory infection, stuffy or runny nose and sore throat, osteoarthritis, arm or leg pain
Uncommon: dizziness, constipation, itching
Rare: reduced number of platelets
Frequency not known: kidney problems (sometimes requiring dialysis), vomiting, joint pain, muscle pain, back pain, interstitial lung disease, bullous pemphigoid (a type of skin blister)
Some patients have experienced the following side effects while taking metformin alone:
Very common: nausea, vomiting, diarrhoea, stomachache and loss of appetite. These symptoms may happen when you start taking metformin and usually go away
Common: a metallic taste
Very rare: decreased vitamin B12 levels, hepatitis (a problem with your liver), hives, redness of the skin (rash) or itching

Ingredients

What Treviamet contains
– The active substances are sitagliptin and metformin. Each film-coated tablet (tablet) contains sitagliptin phosphate monohydrate equivalent to 50 mg of sitagliptin and 1,000 mg of metformin hydrochloride.
– The other ingredients are: In the tablet core: microcrystalline cellulose (E460), povidone K 29/32 (E1201), sodium lauryl sulfate, and sodium stearyl fumarate. In addition, the film coating contains: poly(vinyl alcohol), macrogol 3350, talc (E553b), titanium dioxide (E171), iron oxide red (E172), and iron oxide black (E172).

Delivery

Delievry time are estimates. Can vary due to the time of day you order.

Delivery time estimate are subject to the courier company.

Shipping to Lagos cost starts from N1850 Next day delivery

Shipping to Rest Of Nigeria – 2-3 days cost starts from N2000

Shipping to Rest of Africa –  5-7 working days Cost starts from N12000

Shipping to Europe 7 – 14 working days Cost srats from N18000

Shipping to Rest of the world – 7 – 14 days Cost starts from N18000

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