Zestoretic 20 – lisinopril 20g hydrochlorothiazide 12.5mg, 28 Tablets
Treat high blood pressure.
Helps prevent strokes, heart attacks, and kidney problems.
Active ingredients: lisinopril 20g hydrochlorothiazide 12.5mg
Original price was: ₦31,000.00.₦30,770.00Current price is: ₦30,770.00. — or subscribe and save 10%
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Zestoretic 20 – lisinopril 20g hydrochlorothiazide 12.5mg, 28 Tablets
Zestoretic 20 is a medication used to treat hypertension, or high blood pressure. It contains two active ingredients, lisinopril and hydrochlorothiazide, which work together to lower your blood pressure. But what sets Zestoretic apart from other medications is its unique formulation. See, most hypertension medications only contain one active ingredient.
If you\’re struggling with high blood pressure, you\’re not alone. According to the Centers for Disease Control and Prevention, 1 in 3 adults in the Nigeria has high blood pressure. But the good news is that there are treatments available that can help lower your blood pressure and keep it under control. One option is Zestoretic 20, a medication that contains two medicines (lisinopril and hydrochlorothiazide) that work together to help lower blood pressure.
Zestoretic 20 is a once-daily medication that\’s easy to take, and it\’s been proven to be effective at lowering blood pressure. In clinical studies, Zestoretic 20 has been shown to lower blood pressure in adults with hypertension
Can someone who is pregnant or breastfeeding use Zestoretic 20?
Pregnancy
You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Zestoretic before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Zestoretic. Zestoretic is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Breast-feeding
Tell your doctor if you are breast-feeding or about to start breast-feeding. Zestoretic is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Zestoretic 20 Reviews
After using Zestoretic 20, it\’s helpful to let others know about your experience. Reviews of an item help other users know that medicines received have helped the condition it is claimed for, how well the treatment worked or any issues to be aware of. We invite our users to leave a review of both their treatment and of the service provided. Click on the reviews tab to see if there has been feedback on this item.
What is the price of Zestoretic 20 in Nigeria?
The price of Zestoretic 20 is N5,900
Where can you buy Zestoretic 20 In Nigeria?
You can Buy Zestoretic 20 at Asset Pharmacy Lagos Nigeria, Nigeria\’s Largest Online Pharmacy.
Zestoretic 20is a prescription drug that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent.
You will be required to send Asset Pharmacy your prescription
Brand
Zestoretic
How to Use
How to use Zestoretic 20
Always take Zestoretic exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.
Once you have started taking Zestoretic your doctor may take blood tests. Your doctor may then adjust your dose so you take the right amount of medicine for you.
Taking your medicine
- Swallow the tablet with a drink of water.
- Try to take your tablets at the same time each day. It does not matter if you take Zestoretic before or after food.
- Keep taking Zestoretic for as long as your doctor tells you to, it is a long term treatment. It is important to keep taking Zestoretic every day.
Taking your first dose
- Take special care when you have your first dose of Zestoretic or if your dose is increased. It may cause a greater fall in blood pressure than later doses.
- This may make you feel dizzy or light-headed. If this happens, it may help to lie down. If you are concerned, please talk to your doctor as soon as possible.
Adults
- The recommended dose is one tablet once a day. Your doctor will prescribe the tablet that is the right strength for you.
- If necessary, your doctor may increase your dose to two tablets once a day.
Use in children
- Zestoretic is not recommended for use in children.
If you take more Zestoretic than you should
If you take more Zestoretic than prescribed by your doctor, talk to a doctor or go to a hospital immediately. Take the medicine pack with you so that the tablets can be identified.
If you forget to take Zestoretic
- If you forget to take a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
- Do not take a double dose to make up for a forgotten dose.
If you stop taking Zestoretic
Do not stop taking your tablets, even if you are feeling well, unless your doctor tells you to.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Product Details
Product Information of Zestoretic 20
What you need to know before you take Zestoretic
Do not take Zestoretic:
- if you are allergic to lisinopril or hydrochlorothiazide or any of the other ingredients of Zestoretic (listed in section 6).
- if you are allergic to ACE inhibitor or sulphonamide medicines. If you are not sure if this applies to you, please ask your doctor.
- if you have ever had sudden swelling of the hands, feet, ankles, face, lips, tongue or throat, especially if this followed treatment with an ACE inhibitor. It may also have been difficult to swallow or breathe.
- If you have taken or are currently taking sacubitril/valsartan, a medicine used to treat a type of long-term (chronic) heart failure in adults, as the risk of angioedema (rapid swelling under the skin in an area such as the throat) is increased.
- if you have hereditary angioedema (a condition that makes you more prone to the swelling described above). If you are not sure if this applies to you, please ask your doctor.
- if you have severe kidney problems.
- if you have stopped passing water (urine).
- if you have severe liver problems.
- if you are more than 3 months pregnant. (It is also better to avoid Zestoretic in early pregnancy – see the sections on ‘Pregnancy and breast-feeding’).
- if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.
Do not take Zestoretic if any of the above applies to you. If you are not sure, talk to your doctor or pharmacist before taking Zestoretic.
Warnings and precautions
Talk to your doctor or pharmacist before taking Zestoretic:
- if you have had skin cancer or if you develop an unexpected skin lesion during the treatment. Treatment with hydrochlorothiazide, particularly long term use with high doses, may increase the risk of some types of skin and lip cancer (non-melanoma skin cancer). Protect your skin from sun exposure and UV rays while taking Zestoretic.
- if you have a narrowing (stenosis) of the aorta (an artery in your heart), the heart valves (mitral valves) or the kidney artery.
- if you have an increase in the thickness of the heart muscle (known as hypertrophic cardiomyopathy).
- if you have problems with your blood vessels (collagen vascular disease).
- if you have low blood pressure. You may notice this as feeling dizzy or light-headed, especially when standing up.
- if you have kidney problems or you are having kidney dialysis or you have had a kidney transplant.
- if you have liver problems.
- if you have diabetes.
- if you are taking any of the following medicines used to treat high blood pressure:
- an angiotensin II receptor blocker (ARBs) (also known as sartans – for example valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney problems.
- aliskiren.
Your doctor may check your kidney function, blood pressure and the amount of electrolytes (e.g. potassium) in your blood at regular intervals. See also information under the heading “Do not take Zestoretic”.
- if you have recently had diarrhoea or vomiting (being sick).
- if your doctor has told you to control the amount of salt in your diet.
- if you have high levels of cholesterol and you are having a treatment called ‘LDL apheresis’.
- if you have ever had a condition called systemic lupus erythematosus (SLE).
- if you are of black origin as Zestoretic may be less effective. You may also more readily get the side effect ‘angioedema’ (a severe allergic reaction with swelling of the hands, feet, ankles, face, lips, tongue or throat).
- if you are taking any of the following medicines, the risk of angioedema (rapid swelling under the skin in area such as the throat) is increased:
- temsirolimus, sirolimus, everolimus and other medicines belonging to the class of mTOR inhibitors (used to avoid rejection of transplanted organs and for cancer).
- Racecadotril, a medicine used to treat diarrhoea;
- Vildagliptin, a medicine used to treat diabetes.
- If you experience a decrease in vision or eye pain. These could be symptoms of fluid accumulation in the vascular layer of the eye (choroidal effusion) or an increase of pressure in your eye and can happen within hours to a week of taking Zestoretic. This can lead to permanent vision loss, if not treated. If you earlier have had a penicillin or sulfonamide allergy, you can be at higher risk of developing this.
You must tell your doctor if you think you are (or might become) pregnant. Zestoretic is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see the sections on ‘Pregnancy and breast-feeding’).
If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before taking Zestoretic.
Treatment for allergies such as insect stings
Tell your doctor if you are having or are going to have treatment to lower the effects of an allergy such as insect stings (desensitisation treatment). If you take Zestoretic while you are having this treatment, it may cause a severe allergic reaction.
Operations
If you are going to have an operation (including dental surgery) tell the doctor or dentist that you are taking Zestoretic. This is because you can get low blood pressure (hypotension) if you are given certain local or general anaesthetics while you are taking Zestoretic.
Other medicines and Zestoretic
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This includes medicines that you buy without a prescription and herbal medicines. This is because Zestoretic can affect the way some medicines work and some medicines can have an effect on Zestoretic. Your doctor may need to change your dose and/or to take other precautions.
In particular, tell your doctor or pharmacist if you are taking any of the following medicines:
- Other medicines for treatment of high blood pressure (antihypertensives).
- An angiotensin II receptor blocker (ARB) or aliskiren, (see also information under the headings “Do not take Zestoretic” and “Warnings and precautions”).
- Medicines associated with low blood potassium (hypokalaemia) such as other diuretics (“water tablets” including those which conserve potassium, laxatives, corticosteroids (e.g. prednisone), ACTH (A hormone), amphotericin (an antifungal medicine) and salicylic acid derivatives.
- Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen or indomethacin, used to treat muscle pain or arthritis.
- Medicines for depression (tricyclic and tetracyclic antidepressants).
- Medicines for mental problems such as lithium.
- Aspirin (acetylsalicylic acid), if you are taking more than 3 grams each day.
- Potassium supplements (including salt substitutes), potassium-sparing diuretics and other medicines that can increase the amount of potassium in your blood (e.g. trimethoprim and co-trimoxazole for infections caused by bacteria; ciclosporin, an immunosuppressant medicine used to prevent organ transplant rejection; and heparin, a medicine used to thin blood to prevent clots).
- Calcium salts or Vitamin D supplements.
- Medicines for diabetes (insulin and oral antidiabetics such as sulphonylureas). Your dose of antidiabetic medicine may need to be changed when taking thiazide diuretics.
- Medicines to treat asthma.
- Medicines to treat nose or sinus congestion or other cold remedies (including those you can buy in the pharmacy).
- Medicines to suppress the body’s immune response (immunosuppressants, such as ciclosporin).
- Allopurinol (for gout).
- Medicines for uneven heart beat problems (such as procainamide).
- Heart medicines (e.g. digoxin) or other medicines to control the rhythm of your heart.
- Gold injections (such as sodium aurothiomalate), usually used to treat rheumatoid arthritis.
- Amphotericin B injection (to treat fungal infections).
- Carbenoxolone (to treat ulcers or inflammation in the gullet or in and around the mouth).
- Corticosteroids (steroid medicines).
- Corticotropin (a hormone).
- Medicines to treat constipation (stimulant laxatives).
- Colestyramine and colestipol (to lower cholesterol, prevent diarrhoea or reduce itching).
- Muscle relaxants such as tubocurarine.
- Trimethoprim (an antibiotic).
- Sotalol (a beta-blocker).
- Lovastatin (to lower cholesterol).
- Dextran sulphate (used in the treatment called ‘LDL apheresis’ to lower cholesterol).
The following medicines may increase the risk of angioedema (signs of angioedema include swelling of the face, lips, tongue and/or throat with difficulty in swallowing or breathing):
- Medicines to break up blood clots (tissue plasminogen activator), usually given in hospital.
- Medicines which are most often used to avoid rejection of transplanted organs (temsirolimus, sirolimus, everolimus and other medicines belonging to the class of mTOR inhibitors). See section 2 “Warnings and precautions”.
- Racecadotril used to treat diarrhoea.
- Vildagliptin, a medicine used to treat diabetes.
- Other medicines known to have an effect on the heart called Torsades de pointes.
Low blood pressure may be aggravated by alcohol, barbiturates or anaesthetics. You may notice dizziness when standing up.
Pregnancy and breast-feeding
Pregnancy
You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Zestoretic before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Zestoretic. Zestoretic is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy.
Breast-feeding
Tell your doctor if you are breast-feeding or about to start breast-feeding. Zestoretic is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely.
Driving and using machines
- This medicine may cause occasional dizziness or tiredness which may have an effect on your ability to drive or use machines, especially at the start of treatment or when the dose is adjusted, or in combination with alcohol. If this happens to you, do not drive or use any tools or machines.
- You must wait to see how your medicine affects you before trying these activities.
Side Effects
Side Effects of Zestoretic 20
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Zestoretic contains two medicines: lisinopril and hydrochlorothiazide. The following side effects have been seen with these individual medicines. This means they could also happen with Zestoretic.
Your doctor may take blood samples from time to time to check whether Zestoretic has had any effect on your blood.
Possible side effects with lisinopril
Severe allergic reactions (rare, may affect up to 1 in 1,000 people)
If you have a severe allergic reaction, stop taking Zestoretic and see a doctor immediately.
The signs may include sudden onset of:
- Swelling of your face, lips, tongue or throat. This may make it difficult to swallow.
- Severe or sudden swelling of your hands, feet or ankles.
- Difficulty breathing.
- Severe itching of the skin (with raised lumps).
Severe liver problems (very rare, may affect up to 1 in 10,000 people)
The signs may include:
- Yellowing of your skin or eyes, dark coloured urine or a loss of appetite.
If this happens to you, see a doctor immediately.
Other possible side effects:
Common (may affect up to 1 in 10 people)
- Headache.
- Feeling dizzy or light-headed, especially if you stand up quickly.
- Fainting.
- Diarrhoea.
- Being sick (vomiting).
- Cough.
- Kidney problems (shown in a blood test).
Uncommon (may affect up to 1 in 100 people)
- Mood changes including feeling depressed.
- Tingling feeling such as ‘pins and needles’.
- Spinning feeling (vertigo).
- Changes in the way things taste.
- Difficulty in sleeping.
- A very big drop in blood pressure may happen in people with the following conditions: coronary heart disease; narrowing of the aorta (a heart artery), kidney artery or heart valves; an increase in the thickness of the heart muscle. If this happens to you, you may feel dizzy or light-headed, especially if you stand up quickly.
- Heart attack or stroke.
- Unusual heart beat.
- Change of colour in your fingers or toes.
- Runny nose.
- Feeling sick (nausea).
- Stomach pain and indigestion.
- Changes in blood tests that check how the liver is working.
- Rash.
- Itching.
- Being unable to get an erection (impotence).
- Feeling weak.
- Feeling tired.
- Increased levels of certain substances in your blood (urea, creatinine or potassium).
Rare (may affect up to 1 in 1,000 people)
- Changes to some of the cells or other parts of your blood. The signs may include feeling tired and pale skin.
- Feeling confused.
- Changes in the way things smell.
- Dry mouth.
- Skin rash with dark red, raised, itchy bumps (hives).
- Hair loss (alopecia).
- Psoriasis (a skin problem).
- Infection of the blood.
- Kidney failure.
- Enlarged breasts in men.
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
- Low levels of sodium in the blood, which may cause weakness, tiredness, headache, feeling sick, being sick (vomiting) and cramps.
Very rare (may affect up to 1 in 10,000 people)
- Problems with your bone marrow or a reduced number of blood cells and/or platelets in your blood. You may notice tiredness, an infection (which may be serious), fever, feeling breathless or that you bruise or bleed more easily.
- Swollen glands (lymph nodes).
- Increased immune response (autoimmune disease).
- Low levels of sugar in your blood (hypoglycaemia). The signs may include feeling hungry or weak, sweating and a fast heart beat.
- Suddenly feeling wheezy or short of breath (bronchospasm).
- Lung inflammation (which may make you feel breathless).
- Sinusitis (a feeling of pain and fullness behind your cheeks and eyes).
- Eosinophilic pneumonia. The signs include a combination of the following:
- sinusitis
- feeling like you have flu
- feeling more and more breathless
- pain in the area of your stomach or gut
- skin rash
- a feeling of ‘pins and needles’ or numbness of your arms or legs.
- Inflammation of the pancreas. This causes moderate to severe pain in the stomach.
- Swelling of the lining of the gut. This may cause sudden stomach pain, diarrhoea or make you be sick (vomit).
- Sweating.
- Severe skin disorder or rash. The symptoms include redness, blistering and peeling of the skin which may develop quickly and may include blistering in the mouth and nose.
- Passing less water (urine) than normal or passing no water.
Not known (frequency cannot be estimated from the available data)
- Seeing, feeling or hearing things that are not there (hallucinations).
- Flushing of your skin.
Possible side effects with hydrochlorothiazide (frequency not known)
- Skin and lip cancer (Non-melanoma skin cancer).
- Inflammation of a salivary gland.
- A reduced number of blood cells and/or platelets in your blood. You may notice tiredness, an infection (which may be serious), fever, feeling breathless or that you bruise or bleed more easily.
- Loss of appetite.
- An increase in the amount of sugar (glucose) in your blood (hyperglycaemia).
- Sugar in your urine.
- An increase in the amount of uric acid in your blood.
- Altered levels of substances in your blood (for example low sodium and potassium). You may notice muscle weakness, thirst, ‘pins and needles’, cramps or feeling sick.
- Raised or high levels of fats in your blood (including cholesterol).
- Feeling restless.
- Depression.
- Difficulty sleeping.
- Tingling feelings such as ‘pins and needles’.
- Feeling light headed.
- Changes to your vision that can make things look yellow.
- Problems with your sight for a short time.
- Severe eye pain with redness and sudden blurred vision. If you have a suddenly painful red eye tell your doctor immediately; you may need treatment to avoid permanent loss of vision.
- A spinning feeling (vertigo).
- Feeling faint (especially when standing up).
- Damage to blood vessels causing red or purple spots in the skin.
- Difficulty breathing. You may feel breathless if your lungs get inflamed or have fluid on them.
- Stomach irritation.
- Diarrhoea.
- Constipation.
- Inflammation of the pancreas. This causes moderate to severe pain in the stomach.
- Yellowing of your skin or the whites of your eyes (jaundice).
- Skin problems including rash caused by sensitivity to sunlight, rash, severe rash that develops quickly with blistering or peeling of the skin and possibly blistering in the mouth, activating or worsening of existing lupus conditions or appearance of unusual skin reactions.
- Allergic reactions.
- Muscle cramps and muscle weakness.
- Kidney problems which may be severe (shown in blood tests).
- Fever.
- Weakness.
- Decrease in vision or pain in your eyes due to high pressure (possible signs of fluid accumulation in the vascular layer of the eye (choroidal effusion) or acute angle-closure glaucoma).
Do not be concerned by this list of possible side effects. You may not get any of them.
Reporting of side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet
Ingredients
Product Ingredients of Zestoretic 20
The active substances are lisinopril (as dihydrate) and hydrochlorothiazide.
- Zestoretic 20 mg/12.5 mg Tablets contain 20 mg of lisinopril and 12.5 mg of hydrochlorothiazide.
The other ingredients are calcium hydrogen phosphate dihydrate, magnesium stearate, maize starch, mannitol and pregelatinised starch. Zestoretic 10 mg/12.5 mg Tablets also contain iron oxide (E172).
How to store
How to store Zestoretic 20
- Keep this medicine out of the sight and reach of children.
- Do not use this medicine after the expiry date which is stated on the blister strip and the carton. The expiry date refers to the last day of that month.
- Store your tablets below 30°C. Always keep the blister strip in the carton to protect your tablets from light.
- Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
Prescription Product
This product requires a prescription from your Doctor.
Please follow the instruction received from the pharmacy on how to forward your prescription to the pharmacy after you have paid for the medicine.
A prescription drug is a pharmaceutical medication that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent
Patient Information Leaflet
Click here for the Patient Information Leaflet of Zestoretic 20
Delivery
Delievry time are estimates. Can vary due to the time of day you order.
Delivery time estimate are subject to the courier company.
Shipping to Lagos cost starts from N1850 Next day delivery
Shipping to Rest Of Nigeria – 2-3 days cost starts from N2000
Shipping to Rest of Africa – 5-7 working days Cost starts from N12000
Shipping to Europe 7 – 14 working days Cost srats from N18000
Shipping to Rest of the world – 7 – 14 days Cost starts from N18000
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