- Additional information
- How to Use
- Product Details
- Side Effects
- How to store
- Patient Information Leaflet
- Prescription Product
Amitriptyline 25mg Tablets, 28 Tablets
If you’re looking for an antidepressant that’s both effective and affordable, Amitriptyline 25mg Tablets are perfect for you. The active ingredient, Amitriptyline, belongs to a group of medicines known as tricyclic antidepressants. These tablets can be taken orally, and they start working within a few weeks. Symptoms such as sadness, anxiety, and poor sleep quality will improve with regular use. Plus, at just 10mg per tablet, they’re super easy to take. So why wait? Get started on the road to recovery today with Amitriptyline 10mg Tablets.
What is Amitriptyline used to treat?
Amitriptyline 25mg Tablets is used to treat:
- Depression in adults (major depressive episodes)
- Neuropathic pain in adults
- Chronic tension-type headache prophylaxis in adults
- Migraine prophylaxis in adults
- Bed-wetting at night in children aged 6 years and above, only when organic causes, such as spina bifida and related disorders, have been excluded and no response has been achieved to all other non-drug and drug treatments, including muscle relaxants and desmopressin. This medicine should only be prescribed by doctors with expertise in treating patients with persistent bed-wetting
Can someone who is pregnant or breastfeeding use Amitriptyline 25mg Tablets?
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Amitriptyline is not recommended during pregnancy unless your doctor considers it clearly necessary and only after careful consideration of the benefit and risk
Amitriptyline 25mg Tablets Reviews
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What is the price of Amitriptyline 25mg Tablets in Nigeria?
The price of Amitriptyline 25mg Tablets is N2,990
Where can you buy Amitriptyline 25mg Tablets In Nigeria?
You can Buy Amitriptyline 25mg Tablets at Asset Pharmacy Lagos Nigeria, Nigeria’s Largest Online Pharmacy.
Amitriptyline 25mg Tablets is not available to buy over the counter. You need a prescription to buy Amitriptyline 25mg Tablets
Amitriptyline 25mg Tablets is a prescription drug that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent.
You will be required to send Asset Pharmacy your prescription
How to Use
How to take Amitriptyline Tablets
Always take this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Not all dosage schemes can be achieved with all the pharmaceutical forms/strengths. The appropriate formulation/strength should be selected for the starting doses and any subsequent dose increases
Adults The recommended initial dose is 25 mg two times daily. Depending on the response to the medicine, your doctor may gradually increase the dose to 150 mg per day divided in two doses. Elderly (above 65 years of age) and patients with cardiovascular disease) The recommended initial dose is 10 mg – 25 mg daily. Depending on your response to the medicine, your doctor may gradually increase the dose to a total daily dose of 100 mg divided in two doses. If you receive doses in the range of 100 mg – 150 mg, your doctor may need to do more frequent follow-up with you. Use in children and adolescents This medicine should not be given to children or adolescents for treatment of depression. For further information
Neuropathic pain, chronic tension type headache and migraine prophylaxis
Your doctor will adjust the medication according to your symptoms and your response to the treatment. Adults The recommended initial dose is 10 mg – 25 mg in the evening. The recommended daily dose is 25 mg – 75 mg. Depending on your response to the medicine, your doctor may gradually increase the dose. If you receive doses above 100 mg daily, your doctor may need to do more frequent follow-up with you. Your doctor will instruct you whether to take the doses once daily or divide into two doses. Elderly (above 65 years of age) and patients with cardiovascular disease The recommended initial dose is 10 mg – 25 mg in the evening. Depending on your response to the medicine, your doctor may gradually increase the dose. If you receive doses above 75 mg daily, your doctor may need to do more frequent follow-up with you. Use in children and adolescents This medicine should not be given to children or adolescents for treatments of neuropathic pain, chronic tension type headache prophylaxis and migraine prophylaxis. For further information
Bed-wetting at night Use in children and adolescents
The recommended doses for children: • aged below 6 years: see section 2 Do not take Amitriptyline Tablets • aged 6 to 10 years: 10 mg – 20 mg daily. A suitable dosage form should be used for this age group. • aged 11 years and above: 25 mg – 50 mg. The dose should be increased gradually. Take this medicine 1-1½ hours before bedtime. Before starting treatment, your doctor will conduct an ECG of your heart to check for sign of unusual heartbeat. Your doctor will re-evaluate your treatment after 3 months and if needed perform a new ECG. Do not stop the treatment without consulting your doctor first
What you need to know before you take Amitriptyline Tablets
Do not take Amitriptyline Tablets: • if you are allergic to amitriptyline or any of the other ingredients of this medicine (listed in section 6) • if you recently have had a heart attack (myocardial infarction) • if you have heart problems such as disturbances in heart rhythm which are seen on an electrocardiogram (ECG), heart block, or coronary artery disease • if you are taking medicines known as monoamine oxidase inhibitors (MAOIs) • if you have taken MAOIs within the last 14 days • if you have taken moclobemide the day before • if you have a severe liver disease. • if you have porphyria (a disease of blood proteins affecting the skin, gut and nervous system) If you are treated with Amitriptyline Tablets, you have to stop taking this medicine and wait for 14 days before you start treatment with a MAOI. This medicine should not be used for children below 6 years of age. Warnings and precautions Talk to your doctor or pharmacist before taking Amitriptyline Tablets. Heart rhythm disorders and hypotension may occur if you receive a high dosage of amitriptyline. This might also occur in usual doses if you have pre-existing heart disease. Prolonged QT interval A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG) and heart rhythm disorders (rapid or irregular heart beat) have been reported with Amitriptyline Tablets. Tell your doctor if you: • have slow heart rate, • have or had a problem where your heart cannot pump the blood round your body as well as it should (a condition called heart failure), • are taking any other medication that may cause heart problems, or • have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood • have a surgery planned as it might be necessary to stop the treatment with amitriptyline before you are given anaesthetics. In the case of acute surgery, the anaesthetist should be informed about the treatment of amitriptyline. • have an over active thyroid gland or receive thyroid medication. Thoughts of suicide and worsening of your depression If you are depressed, you can sometimes have thoughts of harming or killing themselves. These may be increased when first starting antidepressants, since these medicines all take time to work, usually about two weeks but sometimes longer. You may be more likely to think like this: • If you have previously had thoughts about killing or harming yourself. • If you are a young adult. Information from clinical trials has shown an increased risk of suicidal behaviour in young adults (less than 25 years old) with psychiatric conditions who were treated with an antidepressant. If you have thoughts of harming or killing yourself at any time, contact your doctor or go to a hospital straight away. You may find it helpful to tell a relative or close friend that you are depressed, and ask them to read this leaflet. You might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour. Episodes of mania Some patients with manic-depressive illness may enter into a manic phase. This is characterized by profuse and rapidly changing ideas, exaggerated gaiety and excessive physical activity. In such cases, it is important to contact your doctor who probably will change your medication. Tell your doctor if you have, or have had in the past, any medical problems, especially if you have • narrow angle glaucoma (loss of vision due to abnormally high pressure in the eye) • epilepsy, a history of convulsions or fits • difficulty in passing urine • enlarged prostate • thyroid disease • bipolar disorder • schizophrenia • severe liver disease • severe heart disease • pylorus stenosis (narrowing of the gastric outlet) and paralytic ileus (blocked intestine) • diabetes as you might need an adjustment of your antidiabetic medicine • phaeochromocytoma (a rare tumour of the adrenal gland). If you use antidepressants such as SSRIs, your doctor might consider changing the dose of your medicine (see also section 2 Other medicines and Amitriptyline Tablets and section 3) Elderly are more likely to suffer from certain side effects, such as dizziness when you stand up due to low blood pressure (see also section 4 Possible side effects). Children and adolescents Depression, neuropathic pain, chronic tension type headache and migraine prophylaxis Do not give this medicine to children and adolescents aged below 18 years for these treatments as safety and efficacy have not been established in this age group. Bed-wetting at night • An ECG should be performed prior to initiating therapy with amitriptyline to exclude long QT syndrome • This medicine should not be taken at the same time as an anticholinergic drug (see also section 2 Other medicines and Amitriptyline Tablets) • Suicidal thoughts and behaviours may also develop during early treatment with antidepressants for disorders other than depression; the same precautions observed when treating patients with depression should therefore be followed when treating patients with enuresis Other medicines and Amitriptyline Tablets Some medicines may affect the action of other medicines and this can sometimes cause serious side effects. Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, such as: • monoamine oxidase inhibitors (MAOIs) e.g. phenelzine, iproniazid, isocarboxazid, nialamide or tranylcypromine (used to treat depression) or selegiline (used to treat Parkinson’s disease). These should not be taken at the same time as Amitriptyline Tablets (see section 2 Do not take Amitriptyline Tablets) • adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (these may be present in cough or cold medicine, and in some anaesthetics) • medicine to treat high blood pressure for example calcium-channel blockers (e.g. diltiazem and verapamil), guanethidine, betanidine, clonidine reserpine and methyldopa • Anticholinergic drugs such as certain medicines to treat Parkinsons disease and gastrointestinal disorders (e.g. atropine, hyoscyamine) • thioridazine (used to treat schizophrenia) • nefopam, tramadol and morphine (painkillers) • medicines to treat fungal infections (e.g. fluconazole, terbinafine, ketoconazole, and itraconazole) • sedatives (e.g. barbiturates) • antidepressants(e.g. SSRIs(fluoxetine, paroxetine, fluvoxamine), duloxetine and bupropion) • medicines for certain heart conditions (e.g. beta blockers and antiarrhythmics) • cimetidine (used to treat stomach ulcers) • methylphenidate (used to treat ADHD) • ritonavir (used to treat HIV) • oral contraceptives • rifampicin (to treat infections) • phenytoin and carbamazepine (used to treat epilepsy) • St. John´s Wort (hypericum perforatum) – a herbal remedy used for depression • thyroid medication • baclofen (muscle relaxant) • nitrate tablets placed under the tongue, such as glyceryl trinitrate, used to treat angina. • valproic acid You should also tell your doctor if you take or have recently taken medicine that may affect the heart´s rhythm. e.g.: • medicines to treat irregular heartbeats (e.g. quinidine and sotalol) • astemizole and terfenadine (used to treat allergies and hayfever) • medicines used to treat some mental illnesses (e.g. pimozide and sertindole) • cisapride (used to treat certain types of indigestion) • halofantrine (used to treat malaria) • methadone (used to treat pain and for detoxification) • diuretics (“water tablets” e.g. furosemide) If you are going to have an operation and receive general or local anaesthetics, you should tell your doctor that you are taking this medicine. Likewise, you should tell your dentist that you take this medicine if you are to receive a local anaesthetic. Amitriptyline Tablets with alcohol It is not advised to drink alcohol during treatment with this medicine as it might increase the sedative effect. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Amitriptyline is not recommended during pregnancy unless your doctor considers it clearly necessary and only after careful consideration of the benefit and risk. If you have taken this medicine during the last part of the pregnancy, the newborn may have withdrawal symptoms such as irritability, increased muscle tension, tremor, irregular breathing, poor drinking, loud crying, urinary retention, and constipation. Your doctor will advise you whether to start/continue/ stop breast-feeding, or stop using this medicine taking into account the benefit of breast-feeding for your child and the benefit of therapy for you. Driving and using machines This medicine may cause drowsiness and dizziness, especially in the beginning of the treatment. Do not drive or work with tools or machinery if you are affected. Amitriptyline Tablets contain tartrazine aluminium lake (E102) and sunset yellow FCF (E110) Amitriptyline 25mg Tablets contain tartrazine aluminium lake (E102) and sunset yellow FCF (E110), which may cause allergic reactions
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you get any of the following symptoms you should see your doctor immediately: – Attacks of intermittent blurring of vision, rainbow vision, and eye pain. You should immediately have an eye examination before the treatment with this medicine can be continued. This condition may be signs of acute glaucoma. Very rare side effect, may affect up to 1 in 10,000 people. – A heart problem called “prolonged QT interval” (which is shown on your electrocardiogram, ECG). Common side effect, may affect up to 1 in 10 people. – Bad constipation, a swollen stomach, fever and vomiting. These symptoms may be due to parts of the intestine becoming paralysed. Rare side effect, may affect up to 1 in 1,000 people. – Any yellowing of the skin and the white in the eyes (jaundice). – Your liver may be affected. Rare side effect, may affect up to 1 in 1,000 people. – Bruising, bleeding, pallor or persistent sore throat and fever. – These symptoms can be the first signs that your blood or bone marrow may be affected. – Effects on the blood could be a decrease in the number of red cells (which carry oxygen around the body), white cells (which help to fight infection) and platelets (which help with clotting). Rare side effect, may affect up to 1 in 1,000 people. – Suicidal thoughts or behaviour. Rare side effect, may affect up to 1 in 1,000 people. – Signs of a severe allergic reaction (anaphylaxis) such as swelling of your tongue or face of difficulty breathing. Side effects listed below have been reported in the following frequencies: Very common: may affect more than 1 in 10 people • sleepiness/drowsiness • shakiness of hands or other body parts • dizziness • headache • irregular, hard, or rapid heartbeat • dizziness when you stand up due to low blood pressure (orthostatic hypotension) • dry mouth • constipation • nausea • excessive sweating • weight gain • slurred or slow speech • aggression • congested nose. Common: may affect up to 1 in 10 people • confusion • sexual disturbances (decreased sex-drive, problems with erection) • disturbance in attention • changes in taste • numbness or tingling in the arms or legs • disturbed coordination • dilated pupils • heart block • fatigue • low sodium concentration in the blood • agitation • urination disorders • feeling thirsty. Uncommon: may affect up to 1 in 100 people • excitement, anxiety, difficultiessleeping, nightmares • convulsions • tinnitus • increased blood pressure • diarrhoea, vomiting • skin rash, nettle rash (urticarial) difficulties passing urine • increased production of breast milk or breast milk outflow without breast feeding • increased pressure in the eye ball • collapse conditions • worsening of cardiac failure • liver function impairment (e.g. cholestatic liver disease). Rare: may affect up to 1 in 1,000 people • decreased appetite • delirium (especially in elderly patients), hallucinations • abnormality in the heart’s rhythm, or heartbeat pattern • swelling of the salivary glands • hair loss • increased sensitivity to sunlight • breast enlargement in men • fever • weight loss • abnormal results of liver function tests. Very rare: may affect up to 1 in 10,000 people • heart muscle disease • feeling of inner restlessness and a compelling need to be in constant motion • disorder of the peripheral nerves • acute increase of pressure in the eye • particular forms of abnormal heart rhythm (so called torsades de pointes) • allergic inflammation of the lung alveoli and of the lung tissue. Not known: frequency cannot be estimated from the available data • absent sensation of appetite • elevation or lowering of blood sugar levels • paranoia • movement disorders (involuntary movements or decreased movements) • hypersensitivity inflammation of heart muscle • hepatitis • hot flush • dry eyes • stomach pain • sore mouth • itching. An increased risk of bone fractures has been observed in patients taking this type of medicines. When used for the treatment of bed wetting in children, the side effects are less frequent. The most common side effects are drowsiness, blurred vision, dilated pupils, constipation, sweating, itching and dry mouth. Changes in behaviour have also occurred in children receiving amitriptyline. Reporting of side e‑ects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.
What Amitriptyline Tablets contain
The active ingredient is: amitriptyline hydrochloride. The tablets are available in three strengths, 25mg.
Amitriptyline 25mg Tablets also contain: Calcium hydrogen phosphate dihydrate, sodium starch glycollate, maize starch, microcrystalline cellulose, magnesium stearate, hypromellose (E464), titanium dioxide (E171), macrogol and indigo carmine aluminium lake (E132).
How to store
How to store Amitriptyline Tablets
Keep this medicine out of the sight and reach of children. • Do not store above 25°C. • Do not use this medicine after the expiry date which is stated on the label and carton. The expiry date refers to the last day of that month. • Do not use this medicine if you notice signs of “going off” such as discolouration. Do not throw medicines away via wastewater or household waste. Ask your pharmacist how to dispose of medicines you no longer use. These measures will help protect the environment.
Patient Information Leaflet
This product requires a prescription from your Doctor.
Please follow the instruction received from the pharmacy on how to forward your prescription to the pharmacy after you have paid for the medicine.
A prescription drug is a pharmaceutical medication that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent
Delievry time are estimates. Can vary due to the time of day you order.
Delivery time estimate are subject to the courier company.
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