Duphaston 10mg Tablets, 20 Tablets

Treatment for menstrual disorders in women 

Hormone replacement therapy

Suitable for Women over 18 years & Over

Active ingredient: Dydrogesterone 10mg


Availability: In Stock
- +

EAN: 08002660030214 SKU: PILLS004 Categories: , Tags: ,

Frequently Bought Together

Duphaston 10mg Tablets, 20 Tablets
Clomid 50mg Tablets, 10 Tablets

Duphaston 10mg Tablets, 20 Tablets

Duphaston 10mg Tablet is a synthetic progestogen (Dydrogesterone) and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders in women caused due to a lack of hormones. It is also used to reduce the risk of miscarriages or abortions. This medicine is not recommended for use in patients below 18 years of age.

What is Duphaston Tablet used for?

Hormone replacement therapy
To counteract the effects of unopposed oestrogen on the endometrium in hormone replacement therapy for women with disorders due to natural or surgical induced menopause with an intact uterus.

Progesterone deficiencies
Treatment of progesterone deficiencies such as:

  • Treatment of dysmenorrhoea
  • Treatment of endometriosis
  • Treatment of secondary amenorrhoea
  • Treatment of irregular cycles
  • Treatment of dysfunctional uterine bleeding
  • Treatment of pre-menstrual syndrome
  • Treatment of threatened and habitual abortion, associated with proven progesterone deficiencies
  • Treatment of infertility due to luteal insufficiency

How does Duphaston work?

Duphaston active ingredient, Dydrogesterone is an orally active progestogen which produces a complete secretory endometrium in an oestrogen primed uterus thereby providing protection for oestrogen induced increased risk for endometrial hyperplasia and/or carcinogenesis. It is indicated in all cases of endogenous progesterone deficiency. Dydrogesterone has no oestrogenic, no androgenic, no thermogenic, no anabolic and no corticoid activity.

Duphaston 10mg Tablets Reviews

After using Duphaston 10mg Tablets, it’s helpful to let others know about your experience. Reviews of an item help other users know that medicines received have helped the condition it is claimed for, how well the treatment worked or any issues to be aware of. We invite our users to leave a review of both their treatment and of the service provided. Click on the reviews tab to see if there has been feedback on this item.

What is the price of Duphaston 10mg Tablets in Nigeria

The price of Duphaston 10mg Tablets is N4300

Where can you buy Duphaston 10mg Tablets In Nigeria?

You can Buy Duphaston 10mg Tablets at Asset Pharmacy Lagos Nigeria, Nigeria’s Largest Online Pharmacy.



Duphaston Tablets

Duphaston tablet's active ingredient, Dydrogesterone.Dydrogesterone is a progestogen that produces an endometrium with complete secretory capabilities in the ovary of all primed by oestrogen. This protects against increased risk for hyperplasia and/or carcinogenesis caused by this hormone's activity, which also has no estrogenic side-effects or toxicological effects on other organs like it does not affect testosterone levels like synthetic estrogens might do due to its natural origin

How to Use

How to use Duphaston

Dosage and administration
Hormone replacement therapy:

  • In combination with continuous oestrogen therapy, one tablet of 10 mg dydrogesterone daily during 14 consecutive days per cycle of 28 days.
  • In combination with cyclical oestrogen therapy, one tablet of 10 mg dydrogesterone daily during the last 12-14 days of oestrogen therapy.
  • If endometrial biopsies or ultrasound would reveal inadequate progestational response, 20 mg dydrogesterone should be prescribed.

10 mg twice daily from day 5 to day 25 of the cycle.

10 mg two or three times daily from day 5 to day 25 of the cycle or continuously.

Dysfunctional uterus bleeding:
Bleeding is triggered with 10 mg twice daily for 5 to 7 days, combined with an oestrogen. Several days after the end of this treatment, withdrawal bleeding will occur. Subsequent heavier bleeding can be prevented by prescribing 10 mg daily prophylactically from the 11th to the 25th day of the cycle.

In case of cystic metropathia haemorrhagica, 10 mg daily are given from the 11th to the 25th day of the cycle.
In some cases it may be necessary to give an oestrogen during the first half of the cycle. Several days after stopping this treatment, withdrawl bleeding will occur. This treatment should preferably be continued for several cycles.

An oestrogen once daily from day 1 to day 25 of the cycle, together with 10 mg dydrogesterone twice daily from day 11 to day 25 of the cycle.

Pre-menstrual syndrome:
10 mg twice daily from day 11 to day 25 of the cycle.

Irregular cycles:
10 mg twice daily from day 11 to day 25 of the cycle.

Threatened abortion:
40 mg at once, then 10 mg every eight hours until symptoms remit.

Habitual abortion:
10 mg twice daily until the twentieth week of pregnancy.

Infertility due to luteal insufficiency:
10 mg daily from day 14 to day 25 of the cycle. Treatment should be maintained for at least six consecutive cycles. It is advisable to continue this treatment for the first few months of pregnancy as described under ‘Habitual abortion’.

Duphaston is not recommented for use in children below age 18 due to insufficient data on safety and efficacy.

Product Details

Product Information of Duphaston

Do not take Duphaston if you:

  • are hypersensitive(allergic) to the active substance or to any of the excipients.
  • have a known or suspected progestogen dependent neoplasm.
  • have undiagnosed vaginal bleeding.
  • are using this medicine to prevent endometrial hyperplasia (abnormal growth of the lining of the uterus), specifically if you are also taking oestrogens: See contraindications for use of oestrogens in combination with progestagens, such as dydrogesterone.

Warnings and special precautions for use
The cause of abnormal bleeding must be investigated (and found if possible) before your doctor can prescribe this medication to you to treat this problem.

Treatment with dydrogesterone has frequently been associated with alterations in liver function, sometimes accompanied by clinical symptoms. If you suffer from acute liver disease, or have a history of liver disease your doctor will carefullly evaluate your case before prescribing this medicine to you. This is particularly necessary, if your liver function test continue to be abnormal. In cases of severe hepatic impairment your doctor will stop the treatment.

Some people experience breakthrough bleeding when treated with dydrogesterone.

Conditions which need supervision
If you have a history of, or currently suffer from porphyria (inherited or aquired disorder, preventing the proper developement of haemoglobin) or depression, and/or if these conditions have been aggravated during pregnancy or previous hormone treatment, you should be closely supervised by your doctor while taking Duphaston. This is necessary because these conditions may recur or be aggravated during treatment with dydrogesterone.

Other conditions
Do not take this medicine if you suffer from any of the following rare hereditery problems:
Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

If you have been prescribed dydrogesterone for the prevention of endometrial hyperplasia (abnormal growth of the inner lining of the uterus) while using oestrogens, be sure to read the “Warnings and precautions” section in the product information leaflet of the oestrogen preparation.

If you suffer from the symptoms of postmenopausal oestrogen deficiency, your doctor can only start you on hormone replacement therapy (HRT) if your symptoms adversely affect your quality of life. Furthermore, you should see your doctor periodically (at least annually). He will reassess the advantages and disadvantages of HRT to you and continue the treatment only if the advantages continue to outweigh the disadvantages.

Medical examination / follow-up

  • Your doctor will take a full medical history (including family history) before starting you on hormone replacement therapy (HRT) or when its use is to be resumed after an interruption. Your doctor will also perform a complete physical examination (including gynaecological (pelvic) and breast examination) as guided by your history and by the contraindications and warnings described in this leaflet. During the treatment period it is highly recommended to have regular check-ups, the frequency and nature of which will be determined by your doctor according to your personal situation. Any changes in your breast must be reported to your doctor immediately. Your doctor can explain to you what types of changes are particularly important to report.
  • In accordance with the current guidelines for healthy women it is important to have regular breast examinations, including mammography, performed. These should be scheduled according to your personal medical needs.

Endometrial hyperplasia (abnormal growth of the inner lining of uterus)

  • Long-term use of oestrogens without the addition of a progestagen increases the chance of endometrial hyperplasia and endometrial carcinoma (cancer) in women with an intact uterus. This risk may largely be prevented by combining the oestrogen therapy for atleast 12 days per cycle with a progestagen, such as dydrogesterone, the active ingredient in Duphaston.

Mammary cancer

  • A randomised placebo-controlled study, the Women’s Health Initiative Study (WHI) and epidemiological studies, including the Million Women Study (MWS) have shown that in women who have taken oestrogen, oestrogen-progestagen combinations or tibolone as hormone replacement therapy for a number of years there is a relative increased risk of breast cancer. For all HRT this increased risk occurs within a couple of years of use and increases as the treatment period continues. The risk returns to pretreatment leven within a couple of years (a maximum of five) after the treatment is discontinued.
    The MWS showed that the relative risk of breast cancer in women who were treated with conjugated equine oestrogens (CEE) or oestradiol (E2) was higher when a progestagen was added. This risk was independent of the dosage schedule used (sequential or continuous administration of progestagen) and the type of progestagen.

Venous thromboembolism

  • Hormone replacement therapy is associated with a higher relative risk for the occurence of a venous thromboembolism (VTE), that is deep vein thrombosis or pulmonary embolism. One randomised controlled study and epidemiological studies report a two to three times higher risk of VTE among users of HRT compared with women who do not use HRT. The chance of VTE is greater during the first year of HRT treatment than thereafter.
  • General risk factors for the occurence of VTE are:
    • A positive personal history;
    • A positive family history;
    • Serious obesity (Body Mass Index greater that 30 kg/m2);
    • Systemic lupus erythematotus (SLE)

There is no consensus regarding the possible role of varicosis in VTE.

  • If you have a previous history of repeated VTE or have thrombophilia (a blood disorder in which there is an increased tendency to form blood clots), you are at an increased risk of VTE. Hormone replacement could increase this risk even further. If you have a previous personal or clear family history of VTE or have suffered repeated spontaneous abortions, your doctor must carry out an investigation to ensure you do not have a thrombophilic predisposition. Until a thorough evaluation of the thrombophilic factors have been carried out or anticoagulant therapy has been started, the use of HRT is contraindicated. If you are already being treated with anticoagulant therapy, your doctor must carefully assess the advantages and disadvantages of HRT treatment before starting you on it.
  • The chance of VTE may be increased temporarily from long-term immobilisation, serious trauma or major surgical operation. If you are a postoperative patient, your doctors will do all that is necessary to help prevent the occurrence of a VTE after your surgery. If you are to undergo an elective surgery (in particular abdominal or orthopaedic surgery of the lower limbs), after which long-term immobilisation is anticipated, your doctor will likely stop your HRT four to six weeks before the operation. Your doctor can restart your HRT when you are fully mobile again.
  • If a VTE develops after starting the therapy, you must stop taking Duphaston (your doctor will discontinue the prescription). Also, contact your doctor immediately if any potentially thromboembolic symptoms occur (for example: painful swelling of a leg, sudden pain in the chest, shortness of breath).

Coronary heart disease

  • Randomised controlled studies have not provided any evidence of a favourable effect of continuous combined conjugated oestrogens and medroxyprogesterone acetate on the risk of coronary heart disease (i.e.: no positive influence on the risk of coronary heart disease seen during HRT). Two large clinical studies (WHI and HERS (Heart and Oestrogen/progestin Replacement Study)) showed a possible increased risk of cardiovascular morbidity during the first year of use and no indications of an overall favourable effect.

Cerebrovascular accident (CVA)

  • In one large randomised clinical trial (WHI study) in healthy women, as a secondary outcome, an increased risk of ischemic CVA was reported during treatment with continuous combined conjugated oestrogens with medroxyprogesterone acetate.

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines including medicines obtained without a prescription.

No interaction studies have been performed.

Pregnancy and lactation
Ask your doctor or pharmacist for advice before taking any medicine during pregnancy.

It is estimated that altogether roughly 35 million women have been treated with dydrogesterone. Although the number of pregnancies is difficult to estimate, as an approximation it can be assumed that foetuses were exposed to dydrogesterone in around nine million pregnancies (this high exposure in pregnancy is due to the fact that dydrogesterone has pregnancy related indications in large parts of the world). From spontaneous surveillance systems to date, there is no evidence that dydrogesterone can not be used during pregnancy. No other relevant epidemiological data on dydrogesterone are available.

However, a recent US case-controlled study investigating 502 cases with hypospadias (deformity of the penis, in which the urethra opens on the underside instead of at the end) and 1286 healthy controls suggested at least a twofold increased risk of second/third degree hypospadias among boys born by mothers who took progestogens (predominantly progesterone) shortly prior or during early pregnancy (information for the doctor: OR 2.2, 95% CI 1.0-5.0).
The causality is unclear. The underlying illness itself (which is the reason for the use of progesterone in pregnancy) may contribute to a potential risk factor for the development of hypospadias in the child. For dydrogesterone, the risk of hypospadias is unknown.

Animal studies have been conducted, however, are insufficient with respect to pregnancy, embryonal/foetal or postnatal development due to major difference in metabolism between rats and humans. The potential risk for humans is unknown.
The limited animal safety data suggest that Duphaston’s active ingredient dydrogesterone has delaying effects on parturition, which is consistent with its progestogenic activity.

There is no evidence that dydrogesterone decreases fertility.

Dydrogesterone is excreted in the milk of nursing mothers. A risk to the suckling child cannot be excluded. Dydrogesterone should not be used during breast-feeding.

Effects on ability to drive and use machines
Dydrogesterone has no or negligible influence on the ability to drive and use machines.

Important information about the ingredients
Lactose monohydrate:
If you have been told by your doctor that you have an intolerance to some sugars, especially lactose, contact your doctor before taking this medicinal product.

Side Effects

Side Effects of Duphaston

Undesirable effects
Like all medicines, Duphaston may cause side effects. If you notice any side effects not mentioned in this leaflet, or if any of the side effects gets serious, please inform your doctor or pharmacist.

The frequencies of study related side effects are ranked according to the following:
Common: Between 1 and 10 cases in 100 treated patients
Uncommon: Less than one case in 100 treated patients
Rare: Less than one case in 1000 treated patients
Very Rare: Less than one case in 10 000 treated patients

The undesirable effects reported in clinical trials and/or in post marketing experience following dydrogesterone therapy are (according to the MedDRA organ classification system):

Blood and the lymphatic system disorders
Very rare: Haemolytic anaemia (low red blood cell count due to destruction of red blood cells)

Immune system disorders
Very rare: Hypersensitivity (allergy)

Nervous system disorders
Common: Migraines/ headache

Hepatobiliary disorders
Uncommon: Abnormal hepatic function (with jaundice, asthenia (weakness) or malaise, and abdominal pain)

Skin and subcutaneous tissue disorders
Uncommon: Allergic dermatitis (e.g. rash, pruritus (itching), urticaria (hives))
Very rare: Angioedema (sudden, non-painful accumulation of fluid under the skin)

Reproductive system and breast disorders
Common: Metrorrhagia (uterine bleeding not associated with menstruation)
Uncommon: Breast pain/ tenderness

General disorders and administration site conditions
Very rare: Oedema (swelling)

Other adverse reactions obtained from the market with unknown frequency in association with dydrogesterone treatment:

Neoplasms benign, malignant and unspecified (incl. cysts and polyps)

  • Increase in size of progestogen dependent neoplasms (e.g.meningioma; see  section “Contraindications”)

Psychiatric disorders

  • Depressed mood

Reproductive system and breast disorders

  • Breast swelling

Undesirable effects that are associated with an oestrogen-progestagen treatment (see also section “Warnings and special precautions for use”):

  • Breast cancer
  • Endometrial hyperplasia (abnormal growth of the inner lining of the uterus), endometrial carcinoma (cancer)
  • Sex hormone dependent tumours (malignant/benign)
  • Venous thrombosis
  • Myocardial infarction (heart attack), cardiovascular accident.

Limited data are available with regard to overdose in humans. Dydrogesterone was well tolerated after oral dosing (maximum daily dose taken to date in humans 360 mg). There are no specific antidotes and treatment should be symptomatic. Aforementioned information is also applicable for overdosing in children.


Product Ingredients

Active Ingredients: 10 mg dydrogesterone

Excipients (nonmedicinal ingredients):
Tablet core:
Lactose monohydrate, hypromellose, maize starch, colloidal anhydrous silica, magnesium stearate

Hypromellose, macrogol 400, titanium dioxide(E171)

Prescription Product

This product requires a prescription from your Doctor.

Please follow the instruction received from the pharmacy on how to forward your prescription to the pharmacy after you have paid for the medicine.

A prescription drug is a pharmaceutical medication that legally requires a medical prescription to be dispensed.
To order this product you confirm that you are under the care of your doctor or consultant and have been given permission by them for purchase, fulfillment & use in treatment with their written consent


Delievry time are estimates. Can vary due to the time of day you order.

Delivery time estimate are subject to the courier company.

Shipping to Lagos cost starts from N1850 Next day delivery

Shipping to Rest Of Nigeria – 2-3 days cost starts from N2000

Shipping to Rest of Africa –  5-7 working days Cost starts from N12000

Shipping to Europe 7 – 14 working days Cost srats from N18000

Shipping to Rest of the world – 7 – 14 days Cost starts from N18000

Back to top
Hi there, How can I help